Cytochrome P450 2E1 antibodies are used in lipid and metabolism studies. Encoded by the CYP2E1 gene, the protein is a member of the cytochrome P450 family of oxidase enzymes, catalysing lipid, steroid and cholesterol synthesis. It is also involved in alcohol and drug metabolism. Now, a new antibody study has revealed that CYP2E1 may play another role in alcohol consumption – that of determining inclination towards alcoholism.
MYH9 encodes a non-muscle heavy chain type 11A Myosin protein, which plays an important role in cytokinesis, cell shape, motility and secretions. MYH9 antibodies are used in cytoskeleton studies as well as disease research. Antibody studies have shown a number of MYH9 polymorphisms, linked to macrothrombocytopenia diseases such as Epstein Syndrome, Alport syndrome and possibly May-Hegglin anomaly (MHA).